Simulating Patient-Specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques
Simulating Patient-specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques – The vast majority of heart attacks occur when there is a sudden rupture of plaques, so-called vulnerable plaques, forming clots that can cause blockages in coronary arteries. The objective of the researchers’ work was to develop a computational tool-set to support the design and analysis of a catheter-based local nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. The goal is to rationally design drug-encapsulated nanoparticles in conjunction with patient-specific attributes and deliver drug locally to the diseased arteries, thereby personalizing and optimizing therapeutic intervention. To that end, a three-dimensional mathematical model of coupled transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis using the Texas Advanced Computing Center’s (TACC) HPC resources. The visualization component of this project, a 14 minute animation, seeks to explain the motivation of the research, the physical mechanism of the proposed solution concept, the mathematical models used, the computational methodology applied for simulation, and the scientific visualization of the results. Researchers Shaolie Hossain, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Thomas JR Hughes, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Visualization and video production Ben …
Texas lawmakers call for drug testing for welfare recipients
Filed under: drug treatment centers in texas
Texas Governor Rick Perry was Wednesday joined by Sen. Tommy Williams, Rep. Brandon Creighton … A person denied can reapply for financial assistance six months after the drug test was administered if he or she completed or are enrolled in a drug …
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Multitasking plasmonic nanobubbles kill some cells, modify others
Filed under: drug treatment centers in texas
The same laser pulse creates smaller nanobubbles around solid gold nanospheres that punch a tiny, temporary pore in the wall of a cell and create an inbound nanojet that rapidly “injects” drugs or genes into the other cells. In their experiments …
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Law Enforcement Blotter 12/3
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The juvenile stated that he consumed a large amount of medication in an attempt to kill himself and the officer called for an ambulance to transport the juvenile for evaluation by MHMR at Brownwood Regional Medical Center. *Texas Department of Public …
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LOS ANGELES – Mechanical venovenous ultrafiltration proved inferior to drug …
Filed under: drug treatment centers in texas
In the Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF), weight loss due to elimination of excess fluid was similar at 96 hours in the two treatment arms. However, renal function was significantly worse in … "I still think …
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